(ivermectin) Contains 5 mg ivermectin/mL
Parasiticide Consult
your veterinarian for assistance in the diagnosis, treatment and control of
parasitism. INTRODUCTION
IVOMEC (ivermectin) Pour-On delivers internal and
external parasite control in one convenient low-volume application. Discovered
and developed by scientists from Merck Research Laboratories, IVOMEC Pour-On
contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocylic lactone
class of endectocides which have a unique mode of action. Compounds of the class
bind selectively and with high affinity to glutamate-gated chloride ion channels
which occur in invertebrate nerve and muscle cells. This leads to
an increase in the permeability of the cell membrane to chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis and death
of the parasite. Compounds of this class may also interact with other
ligand-gated chloride channels, such as those gated by the neurotransmitter
gamma-aminobutyric acid (GABA). The margin of safety for compounds of this
class is attributable to the fact that mammals do not have glutamate-gated
chloride channels, the macrocyclic lactones have a low affinity for other
mammalian ligand-gated chloride channels and they do not readily cross the
blood-brain barrier. INDICATIONS
IVOMEC Pour-On applies at the recommended dose
level of 500 mcg/kg is indicated for the effective control of these parasites.
Gastrointestinal Roundworms
Ostertagia ostertagi (including inhibited
stage) (adults and L4), Haemonchus placei (adults and L4),
Trichostrongylus axei (adults and L4), T. colubrifomis:
(adults and L4), Cooperia oncophora (adults and L4),
Cooperia punctata: (adults and L4), Cooperia
surnabada (adults and L4), Strongyloides papillosus
(adults), Oesophagostomum radiatum (adults and L4),
Trichuris spp. (adults).
Lungworms
Dictyocaulus viviparus
(adults and L4)
Cattle Grubs
Hypoderma bovis, H. lineatum
Mites
Sarcoptes scabiei var. bovis
Lice
Linognathus vituli, Haematophinus eurysternus,
Damalinia bovis, Solenopotes capillatus
Horn Flies
Haematobia irritans
Persistent Activity
IVOMEC Pour-On has been proved to effectively
control infections and to protect cattle from re-infection with Ostertagia
ostertagi, Oesophagostomum radiatum, Haemonchus placei, Trichostrongylus axei,
Cooperia punctata and Cooperia oncophora for 14 days after treatment.
Treatment of Cattle for Horn Flies
IVOMEC Pour-On controls horn flies (Haematobia
irritans) for up to 28 days after dosing. For best results IVOMEC
Pour-On should be part of a parasite control program for both internal and
external parasites based on the epidemiology of these parasites. Consult
your veterinarian or an entomologist for the most effective timing of
applications. Dosage
The does rate is 1 ml for each 22 lb of body
weight. The formulation should be applied along the topline in a narrow
strip extending from the withers to the tailhead. Administration
Squeeze-Measure-Pour System
(8.5 fl oz/250 ml Bottle with 25 ml Metering Cup)
Attach the metering cup to the bottle.
Set the does by turning the top section of the cup to align the correct body
weight with the pointer on the knurled cap. When the body weight is
between markings, use the higher setting.
Hold the bottle upright and squeeze
it to deliver a slight excess of the required dose as indicated by the
calibration lines.
By releasing the pressure, the dose automatically adjusts
to the correct level. Tilt the bottle to deliver the dose. The off (STOP)
position will close the system between dosing. Squeeze-Measure-Pour
System
(33.8 fl oz/1 Liter Bottle with 50 ml Metering Cup)
Attach the metering cup to the bottle.
Set the dose by turning the top section of the cup to align the correct body
weight with the pointer on the knurled cap. When body weight is between
markings, use the higher setting.
Hold the bottle upright and squeeze it to
deliver a slight excess of the required dose as indicated by the calibration
lines.
By releasing the pressure, the dose automatically adjusts to the
correct level. Tilt the bottle to deliver the dose. When 220 lb (10
ml) or 330 lb (15 ml) dose is required, turn the pointer to "STOP" before
delivering the dose. The off (STOP) position will close the system between
dosing. Collapsible Pack
(84.5 fl oz/2.5 L Pack and 169 fl oz/5 L Pack)
Connect the applicator gun to the collapsible
pack as follows:
Attach the open end of the draw-off tubing to the
dosing equipment. (Because the solvents used in the formulation, only the
Protector Drench Gun from Instrument Supplies Limited, or equivalent, is
recommended. Other applicators may exhibit compatibility problems
resulting in locking, incorrect dosage or leakage.)
Replace the shipping cap
with the draw-off cap and tighten down. Attach draw-off tubing to the
draw-off cap.
Gently prime the applicator gun, checking for leaks.
Follow
the manufacturer's directions for adjusting the dose.
When the interval
between uses of the applicator gun is expected to exceed 12 hours, disconnect
the gun and draw-off tubing from the product container and empty the product
from the gun and tubing back into the product container. To prevent
removal of special lubricants from the Protector Drench Gun, the gun and tubing
must not be washed. 20 Liter Pack
(676 fl oz/20 L Pack)
Use dosing equipment (applicator, draw-off
tubing, cap with stem) compatible with IVOMEC® (ivermectin)
Pour-On. Other dosing equipment may be incompatible, resulting in locking,
incorrect dosage and leakage. Follow the dosing equipment manufacture's
directions for adjusting the dose and proper use and maintenance of the dosing
equipment. Connect the dosing applicator and the draw-off tubing to the
container as follows:
Attach the open end
of the draw-off tubing to an appropriate dosing applicator. Attach
draw-off tubing to the cap with the stem. Replace the shipping cap with
the cap having the draw-off tubing. Gently prime the dosing applicator,
checking for leaks.
When the interval between uses
of the applicator gun is expected to exceed 12 hours, disconnect the gun,
draw-off tubing and cap with stem from the product container, empty the product
from the gun and tubing back into the product container and replace the shipping
cap. ANIMAL SAFETY
Studies conducted in the U.S.A. have demonstrated
the safety margin for ivermectin. Based on plasma levels, the topically
applied formulation is expected to be at least as well tolerated by breeding
animals as is the subcutaneous formulation which had no effect on breeding
performance. WARNING
NOT FOR USE IN HUMANS.
Keep this and all drugs out of the reach of children. The
Material safety Data Sheet (MSDS) contains more detailed
occupational safety information. To report adverse effects, obtain an
MSDS or for assistance, contact Merial at 1-888-637-4251.
WARNING! FLAMMABLE!
KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.
This product should not be applied to self or others because it may be
irritating to human skin and eyes and absorbed through the skin. To
minimize accidental skin contact, the user should wear a long-sleeved shirt and
rubber gloves. If accidental skin contact occurs, wash immediately with
soap and water. If accidental eye exposure occurs, flush eyes immediately
with water and seek medical attention .
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RESIDUE
INFORMATION: Cattle must not
be treated within 48 days of slaughter for human consumption. Because
a withdrawal time in milk has not been established, do not use in female
dairy cattle of breeding age. A withdrawal period has not been
established for this product in pre-ruminating calves. Do not use in
calves to be processed for veal. |
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PRECAUTIONS
Store away from excessive heat (104°F/40°C) and protect from
light. Use only in well-ventilated
areas or outdoors.
Close container
tightly when not in use.
Cattle should
not be treated when hair or hide is wet since reduced efficacy may be
experienced.
Do not use when rain is
expected to wet cattle within six hours after treatment.
This product is for application to skin surface only.
Do not give orally or parenterally.
Cloudiness in the formulation may occur when IVOMEC Pour-On is stored at
temperatures below 32°F. Allowing to warm at room temperature will restore
the normal appearance without affecting efficacy.
Antiparasitic activity of ivermectin will be impaired if the
formulation is applied to areas of the skin with mange scabs or lesions, or with
dermatoses or adherent materials, e.g., caked mud or manure.
Ivermectin has been associated with adverse reactions in
sensitive dogs; therefore, IVOMEC Pour-On is not recommended for use in species
other than cattle. When to Treat
Cattle with Grubs
IVOMEC Pour-On effectively controls all stages of
cattle grubs. However, proper timing of treatment is important. For
the most effective results, cattle should be treated as soon as possible after
the end of the heel fly (warble fly) season. While this is not peculiar to
ivermectin, destruction of Hypoderma larvae (cattle grubs) at the period
when these grubs are in vital areas may cause undesirable host-parasite
reactions. Killing Hypoderma lineatum when it is in the esophageal
tissues may cause bloat; killing H. bovis when it is in the
vertebral canal may cause staggering or paralysis. Cattle should be
treated either before or after these stages of grub development.
Cattle treated with IVOMEC Pour-On at the end of the fly
season may be re-treated with IVOMEC during the winter without danger of
grub-related reactions. For further information and advice on a planned
parasite control program, consult your veterinarian.
Environmental Safety
Studies indicate that when ivermectin comes in
contact with soil it readily and tightly binds to the soil and becomes inactive.
Free ivermectin may adversely affect fish and certain aquatic organisms.
Do not contaminate water by direct application or by improper disposal of drug
containers. Dispose of containers in an approved landfill or by
incineration. As with other
avermectins, ivermectin is excreted in the dung of treated animals and can
inhibit the reproduction and growth of pest and beneficial insects that use dung
as a source of food and for reproduction. The magnitude and duration of
such effects are species and life-cycle specific. When used according to
label directions, the product is not expected to have an adverse impact on
populations of dung-dependent insects.
HOW SUPPLIED
IVOMEC Pour-On is available in an 8.5 fl
oz/250 ml bottle or 33.8 fl oz/1 l bottle with a squeeze-measure-pour
system, or in an 84.5 fl oz/2.5 L or 169 oz/5 L collapsible pack, or 676
fl oz/20 L container intended for use with appropriate automatic dosing
equipment. |