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All information provided in these articles is based either on personal experience or information provided by others whose treatments and practices have been discussed fully with a vet for accuracy and effectiveness before passing them on to readers.
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CDT & Vaccination Schedule Print E-mail
Written by Administrator-GL   
Monday, 12 January 2009


(Enterotoxemia, Caseous Lymphandenitis and Tetanus)

NOTE: This Vaccine  includes vaccination of CL (CLA)

Colorado Serum

Clostridium tetani-perfringens Type D-Corynebacterium pseudotuberculosis Bacterin-Toxoid

U.S. Vet. Lic. No.: 188

Active Ingredient(s): The product is a combination of three antigenic substances, namely, Clostridium perfringens type D, Cl. tetani and Corynebacterium pseudotuberculosis. Contains thimerosal as a preservative.

Colorado Serum CDT vaccine

Indications: The product is a combination of three antigenic substances adequate, when administered to healthy sheep according to label directions, to protect against (1) enterotoxemia caused by Cl. perfringens, type D, (2) toxemia caused by Cl. tetani, and (3) to aid in the prevention and control of caseous lymphadenitis, a disease characterized by localized collections of pus in the tissues of the body caused by C. pseudotuberculosis.

Dosage and Administration: Shake before using so that the adjuvant, which may precipitate to some extent while the product is held in inventory, is well distributed at the time of use. Thereafter inject 2 mL subcutaneously (axillary space). Repeat the full 2 mL dose four (4) weeks later (axillary space opposite to the first dose). A booster dose of 2 mL should be administered annually.

I spoke with Colorado Serum and this is what they told me on vaccination scheduling:

Adults: 4-6 wks before kidding, Booster 30 days after kidding, the following year only the annual booster 30-35 days prior to kidding.

Kids: 30 days before weaning and again 30 days after weaning- annual booster.


Slight lameness (soreness) in lambs and lethargy in mature sheep may be observed in a percentage of the animals following vaccination. Sheep are inclined to become depressed or will limp when foreign substances are administered or because of the increased exertion and stimulation of vaccination. While noticeable, these symptoms usually disappear within 24-48 hours and can be considered as minor vaccination reactions. If suggested care is taken in preparing the vaccination equipment and in administering the product there should not be abscessation at the site of injection.

Precaution(s): Store in the dark at 2° to 7°C.

Caution(s): Handling of the product, filling of syringes, etc., should be done as aseptically as possible. Care has been taken to ensure the purity of the preparation at the time of release for marketing. Reasonable precautions should be taken in the field to maintain this condition.

Anaphylactic reactions sometime follow the use of products of this nature. Adrenalin, or an equivalent drug, should be immediately available for use in these instances. Delayed treatment could result in an irreversible reaction.

Sterilize needles and syringes by boiling in clean water.

Use the entire contents when the bottle is first opened. For veterinary use only.

Warning(s): Do not vaccinate within 21 days before slaughter.

Discussion: Caseous lymphadenitis is a chronic disease of sheep, goats, and other small ruminants in which clinical signs and lesions may not be observed for several months after the animals become infected. Causative bacteria are likely to be present on the skin of susceptible animals and exposure may occur through wounds resulting from shearing, scratches, splinters or thorns. Abrasions provide access to the organism which thereafter migrates to the lymph nodes of the body. Exposure may also occur by pulmonary transfer so over-crowding of animals should also be avoided. The disease is not usually fatal but condemnations may run as high as 20% when carcasses are inspected following slaughter. Weakness and emaciation may develop in animals that are not held for slaughter, followed by eventual death.

The disease is manifested in two forms: (1) external abscesses in the superficial (mandibular, prescapular, and prefemoral) lymph nodes and (2) internal abscesses in the visceral organs especially in the lung, liver, and kidney and in the mediastinal, bronchial, and lumbar lymph nodes. Both forms may occur simultaneously. The visceral form of the disease is implicated in the thin ewe syndrome and can cause loss of fertility.

Abscesses and lesions formed in caseous lymphadenitis have a cheesy greenish-yellow to off-white odorless pus surrounded by a capsule. These lesions progressively enlarge. In older abscesses the pus becomes somewhat dry and firm and will form concentric layers within the fibrous capsule. C. pseudotuberculosis is easily isolated from such abscesses and is usually the only organism present.

Once the disease has been introduced into a flock of sheep a relatively large percentage of susceptible animals will be affected. The organism is likely to spread by contamination from ruptured or lanced abscesses or at shearing time. Any infected animals should be shorn last and the shearing equipment thereafter sterilized. It is essential, in the control of caseous lymphadenitis, to exercise strict herd management with careful attention to examination, treatment, separation, and culling of the infected animals.

It has been shown that the product will control caseous lymphadenitis when sheep are vaccinated prior to exposure to the disease. It has also been shown that little or no benefit can be expected when animals with visible signs of the disease are vaccinated. Those showing infection should be immediately culled from the flock and disposed of or held away from those animals that appear to be in good health.

Enterotoxemia is most common in younger sheep and goats being fed a high carbohydrate diet which is a general practice in most feedlots. Animals on grass may also become infected but less frequently. Cl. tetani is found in the intestinal tracts of most animals. It is introduced into tissues in much the same manner as the micro-organism that causes caseous lymphadenitis.

Presentation: Packaged in 10 dose (20 mL) and 50 dose (100 mL) bottles.

NAC No.: 11010102


Essential 3 + T

(formerly Clostridium Perfringens Types C & D - Tetanus Toxoid)

(Colorado Serum)

For use in healthy cattle, sheep and goats to help prevent Cl. enterotoxemia caused by cl. perfringens Types C & D and Type C in healthy swine. Inject SQ or IM 2

ml and repeat in 3-4 weeks. 21-day slaughter withdrawal.  

Essential 3+TColorado Serum


Clostridium Perfringens Types C & D-Tetanus Toxoid

Contents: Purified formalin detoxified filtrates of highly toxic cultures of Clostridium perfringens types C and D micro-organisms and of Tetanus Toxin.

Contains thimerosal as a preservative.

Indications: For the vaccination of healthy cattle, sheep, and goats as an aid in the prevention of enterotoxemia caused by Clostridium perfringens types C and D. For the vaccination of healthy swine as an aid in the prevention of enterotoxemia caused by Clostridium perfringens type C. For the long-term protection against tetanus.

Dosage and Administration: Inject 2 mL subcutaneously or intramuscularly. Repeat the full dose in 3 to 4 weeks.

Precaution(s): Shake well. Each dose must have a proportionate share of the precipitate for proper responses. Use the entire contents when first opened.

I spoke with Colorado Serum and this is what they told me on vaccination scheduling:

Adults: 4-6 wks before kidding, Booster 30 days later, the following year oin the annual booster 30-35 days prior to kidding.

Kids: 30 days before weaning and again 30 days after weaning- annual booster.


Store in dark at 2° to 7°C. Do not freeze.

CAUTION(s): Anaphylactoid reaction sometimes follows administration of products of this nature. If noted, administer adrenaline or equivalent.

For veterinary use only.

WARNING(s): Do not vaccinate with 21 days before slaughter.

Professional Biological Company
4950 York St., P.O. Box 16428

Denver, CO 80216-0428


Bar Vac CD-T

BarVac CD/T Toxoid(Boehringer Ingelheim)  For the immunization of healthy sheep, goats and cattle against enterotoxemia caused by the toxins of Clost. perfringens types C & D (overeating disease) and tetanus. Dosage is 2 ml for sheep, goats and 5 ml for cattle injected SQ or IM. Repeat in 21-28 days, booster annually.

CD/T, the toxoid-(Covexin8), will sometimes cause a "knot" at the injection site. This is evidence that the vaccine is successfully interacting with the goat's immune system. To avoid these "knots," injections can be done inside the loose skin where the front leg meets the goat's body (behind the "armpit," so the speak). Usually, but not always, these "knots" eventually disappear.


Boehringer Ingelheim

Clostridium Perfringens Types C & D-Tetanus Toxoid

U.S. Vet. Lic. No.: 124

Composition: Prepared from cultures of the organisms listed. Alum precipitated.

Indications: Recommended for the vaccination of healthy, susceptible sheep, goats and cattle against enterotoxemia and tetanus caused by the toxins of Clostridium perfringens Types C and D and Clostridium tetani. Although Cl. perfringens Type B is not a significant problem in the U.S.A., immunity may be provided against the beta and epsilon toxins elaborated by Cl. perfringens Type B. This immunity is derived from the combination of Type C (beta) and Type D (epsilon) fractions.

Dosage and Administration:

Cattle: Using aseptic technique, inject 5 mL subcutaneously. Repeat in 21 to 28 days and once annually.

Sheep and Goats: Using aseptic technique, inject 2 mL subcutaneously. Repeat in 21 to 28 days and once annually.

Precaution(s): Store out of direct sunlight at 35-45°F (2-7°C). Avoid freezing. Shake well before using. Use entire contents when first opened.

Caution(s): Anaphylactoid reactions may occur.

Antidote(s): Administer epinephrine.

Warning(s): Do not vaccinate within 21 days before slaughter.

BI 1203-1 3/01

Presentation: 10 cattle doses or 25 sheep/goat doses (50 mL) and 50 cattle doses or 125 sheep/goat doses (250 mL).

NAC No.: 10280111


Last Updated ( Friday, 16 August 2013 )
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