For Use in Swine, Beef Cattle and
Non-lactating Dairy Cattle Only
DESCRIPTION:
Tylan 200 Injection is a sterile solution of tylosin base in 50% propylene
glycol with 4% benzyl alcohol and water for injection. Each m contains 200 mg of
tylosin activity (as tylosin base).
ACTIONS:
Tylan has an antibacterial spectrum that is essentially gram-positive, but it is
also active against certain spirochetes, large viruses, and certain
gram-negative organisms (not including coliforms). It has also been found to be
active against certain Mycoplasma species. 
INDICATIONS:
In beef cattle and non-lactating dairy
cattle, Tylan 200 Injection is indicated for use in the treatment of
bovine respiratory complex (shipping fever, pneumonia) usually associated with
Pasteurella multocida and Actinomyces pyogenes; foot rot (necrotic
pododermatitis) and diphtheria caused by Fusobacterium necorphorum and
metritis caused by Actinomyces pyogenes.
In swine, Tylan 200
Injection is indicated for use in the treatment of swine arthritis caused by
Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.;
swine erysipelas caused by Erysipelothrix rhusiopathiae; acute swine
dysentery associated with Treponema hyodysenteriae when followed by
appropriate medication in the drinking water and/or feed.
ADMINISTRATION AND
DOSAGE: Tylan Injection is
administered intramuscularly.
BEEF CATTLE AND
NON-LACTATING DAIRY CATTLE-Inject
intramuscularly 8 mg per pound of body weight one time daily (1 ml per 25
pounds). Treatment should be continued for 24 hours following remission of
disease signs, not to exceed 5 days. Do not inject more than 10 ml per site.
SWINE-Inject
intramuscularly 4 mg per pound of body weight (1 ml per 50 pounds) twice daily.
Treatment should be continued for 24 hours following remission of disease signs,
not to exceed 3 days. Do not inject more than 5 ml per site.
SIDE EFFECTS:
Side effects consisting of an
edema of the rectal mucosa, anal protrusion, diarrhea, erythema, and pruritus
have been observed in some hogs following the use of tylosin. Discontinuation of
treatment effected an uneventful recovery from the reaction.
CAUTION:
Do not mix Tylan 200 Injection
with other injectable solutions as this may cause a precipitation of the active
ingredients. Do not administer to horses or other equines. Injection of tylosin
in equines has been fatal.
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PRECAUTION:
Adverse reactions, including shock and death may result from overdosage in
baby pigs.
Do not attempt
injection into pigs weighing less than 25 pounds (0.5 m), with the common
syringe. It is recommended that Tylan 50 Injection be used in pigs weighing
less than 25 pounds.
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If tylosin medicated
drinking water is used as a follow-up treatment for swine dysentery the animal
should thereafter receive feed containing 40 to 100 grams of tylosin per ton for
2 weeks to assure depletion of tissue residues.
WARNING:
Discontinue use in cattle 21 days before slaughter. Discontinue use in swine 14
days before slaughter. Do not use in lactating dairy cattle.
A withdrawal period
has not been established for this product in pre-ruminating calves. Do not use
in calves to be processed for veal.
Store at 72°F. (22°C.)
or below.
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