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Send the Message to Go Green with Ecology Gifts and Tees
Eprinex PourOn Print E-mail
Written by Administrator-GL   
Friday, 13 March 2009
Merial
 
(eprinomectin)
Parasiticide
Contains 5 mg eprinomectin/mL

For Treatment and Control of Internal and External Parasites
NOTE from Administrator: This is a cattle product but is commonly used on goats as Off Label- we use it at the rate of 1cc/20lbs in a syringe with no needle dribbles along the back line from neck to tail- directly on the skin for the control and effective removal of Biting lice and other external parasites. Even though this is also a dewormer, it is not effective as a dewormer on goats- Only as an external parasite control- you still need to deworm your goats for internal parasites. Ivermectin pour-on is the only effective parasite control I have seen that effectively rids the goat of Biting lice-

The broadest-spectrum parasite control product available. Only EPRINEX® kills 42 species and stages of internal and external parasites, including roundworms, lungworms, grubs, mange mites, horn flies, and biting and sucking lice. Backed by Merial's Satisfaction Guarantee! EPRINEX® is weatherproof and has no meat withdrawal or milk withholding. Apply along back at 5 ml per 100 lb body weight.
Eprinex PourOn
See the bottle

Residue Information:  Zero Slaughter Withdrawal, Zero Milk Discard

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

INTRODUCTION
IVOMEC EPRINEX Pour-On delivers highly effective internal and external parasite control in one application.  Discovered and developed by scientists from Merck Research Laboratories, IVOMEC EPRINEX Pour-On contains eprinomectin, a unique avermectin.  Its broad-spectrum efficacy in a weather proof formulation, margin of safety, zero slaughter withdrawal and zero milk discard, make it a convenient product for parasite control in beef and dairy cattle, including lactating dairy cattle.

MODE OF ACTION
Eprinomectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.  Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.

this leads to an increase in the permeability of the cell membrane to chloride ions with hyperpoloarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.  Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do  not readily cross the blood-brain barrier.

INDICATIONS
IVOMEC EPRINEX (eprinomectin) Pour-On is indicated for the treatment and control of gastronintestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.  Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve  a dose level of 500 mcg eprinomectin/kg body weight, IVOMEC EPRINEX Pour-On is indicated for the effective treatment and control of the following parasites.

Gastrointestinal Roundworms
Haemonchus placei (adults and L4), Ostertagia ostertagi (including inhibited L4) (adults and L4), Trichostrongylus axei (adults and L4), Trichostrongylus colubriformis (adults and L4), Trichostrongylus longispicularis (adults only), Cooperia oncophora (adults and L4), Cooperia punctata (adults and L4), Cooperia surnabada (adults and L4), Nematodirus helvetianus (adults and L4), Oesophagostomum radiatum (adults and L4), Bunostomum phlebotomum (adults and L4), Strongyloides papillosus, (adults only), Trichuris spp. (adults only)

Lungworms
Dictyocaulus viviparus (adults and L4).

Cattle Grubs (all parasitic stages)
Hypoderma lineatum, Hypoderma bovis

Lice
Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.

Mange Mites
Chorioptes bovis, Sarcoptes scabiei

Horn Flies
Haematobia irritans

Persistent Activity
IVOMEC EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Cooperia oncophora, Cooperia punctata, Cooperia surnabada, nematodirus helvetianus, Ostertagia ostertagi, Oesophagostomum radiatum and Dictyocaulus viviparus for 28 days after treatment, Haemonchus placei, Trichostrongylus axei and Trichostrongylus colubriformis for 21 days after treatment and Haematobia irritans for 7 days after treatment.

Use Conditions
Varying weather conditions, including rainfall, do not affect the efficacy of IVOMEC EPRINEX Pour-On.

Management Considerations for Treatment of External Parasites
For best results IVOMEC EPRINEX Pour-On should be applied to all cattle in the herd.  Cattle introduced to the herd later should be treated prior to introduction.  Consult your veterinarian or an entomologist for the most effective timing of applications for the control of external parasites.

Chorioptic Mange:  in clinical studies evaluating the efficacy of IVOMEC EPRINEX Pour-On against chorioptic mange mites, mites were not recovered from skin scrapings taken 8 weeks after treatment; however, chronic skin lesions were still present on some animals.

Horn flies:  For optimal control of horn flies, as IVOMEC EPRINEX Pour-On provides 7 days of persistent activity against horn flies, the product should be used as part of an integrated control program utilizing other control methods to provide extended control.

DOSAGE
the product is formulated only for external application to beef and dairy cattle.  The dose rate is 1 mL/10 kg (22 lb) of body weight.  The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.

ADMINISTRATION
Squeeze-Measure-Pour System (250 mL/8.5 fl oz Bottle with 25 mL Metering Cup)
Attach the metering cup to the bottle.

Set the dose by turning the top section of the cup to align the correct body weight with the pointer on the knurled cap.  When body weight is between markings, use the higher setting.

Hold the bottle upright and squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines.  By releasing the pressure, the dose automatically adjusts to the correct level.  the off (STOP) position will close the system between dosing.  Tilt the bottle to deliver the dose.

Squeeze-Measure-Pour System (1 Liter/33.8 fl oz Bottle with 50 mL Metering Cup)
Attach the metering cup to the bottle.

Set the dose by turning the top section of the cup to align the correct body weight with the pointer on the knurled cap.  When body weight is between markings, use the higher setting.

Hold the bottle upright and squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines.

By releasing the pressure, the dose automatically adjusts to the correct level.  When a 220 lb (10 mL) or 330 lb (15 mL dose is required, turn the pointer to "STOP" before delivering the dose.  The off (STOP) position will close the system between dosing.  Tilt the bottle to deliver the dose.

Collapsible Pack (2.5 L/84.5 fl oz and  5 L/169 fl oz Packs)
Connect the dosing applicator and draw-off tubing to the collapsible pack as follows:

Attach the open end of the draw-off tubing to an appropriate dosing applicator.  Attach the draw-off tubing to the cap with the stem that is included in the pack.  Replace the shipping cap with the cap having the draw-off tubing.  Gently prime the dosing applicator, checking for leaks.  Follow the dosing applicator manufacturer's directions for adjusting the dose and proper use and maintenance of the dosing applicator and draw-off tubing.

20 Liter Pack (20 L/676 fl oz Pack)
Connect the dosing applicator and draw-off tubing to the container as follows:

Attach the open end of the draw-off tubing to an appropriate dosing applicator.  Attach draw-off tubing to the cap with the stem.  Replace the shipping cap with the cap having the draw-off tubing.  Gently prime the dosing applicator, checking for leaks.  Follow the dosing applicator manufacturer's directions for adjusting the dose and proper use and maintenance of the dosing applicator and draw-off tubing.

ANIMAL SAFETY
Tolerance and toxicity studies have demonstrated the margin of safety for prinomectin in cattle.  In toxicity studies, application of 3 times the recommended dose had no adverse effects on neonatal calves, and application of up to 5 times the recommended dose 3 times at 7 day intervals had no adverse effects on 8 week old calves.  In the tolerance study, one of 6 cattle treated once at 10 times the recommended dose showed clinical signs of mydriasis.  Application of 3 times the recommended dose had no adverse effect on breeding performance of cows or bulls.

Residue Information:  when used according to label directions, neither a pre-slaughter drug withdrawal period nor a milk discard time is required, therefore, meat and milk from cattle treated with IVOMEC EPRINEX (eprinomectin) Pour On may be used for human consumption at any time following treatment.

WARNING
Keep this and all drugs out of the reach of children.

NOT FOR USE IN HUMANS.
As with any topical medication intended for treatment of animals, skin contact should be avoided.  If accidental skin contact occurs, wash immediately with soap and water.  If accidental eye exposure occurs, flush eyes immediately with water.  the material safety data sheet (MSDS)  contains more detailed occupational safety information.  To report adverse effects, obtain an MSDS or for assistance, contact Merial at 1-888-637-4251.

PRECAUTIONS
this product is for topical application only.  Do not administer orally or by injection.

Do not apply to areas of the backline covered with mud or manure.

IVOMEC EPRINEX Pour-On is not recommended for use in species other than cattle.  Severe adverse reactions have been reported in other species treated with products containing compounds of this class.

Restricted Drug - use only as directed (California).

When to Treat Cattle with Grubs
IVOMEC EPRINEX P-our-On is highly effective against all stages of cattle grubs.  However, proper timing of treatment is important.  For the most effective results, cattle should be treated as soon as possible after the end of the hell fly (warble fly) season.  While this is not peculiar to eprinomectin, destruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable host-parasite reactions.  Killing Hypoderma lineatum when it is in the esophageal tissues may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis.  Cattle should be treated wither before or after these stages of grub development.

Cattle treated with IVOMEC EPRINEX P-our-On at the end of the fly season may be re-treated with IVOMEC EPRINEX Pour-On during the winter without danger of grub-related reactions.  For further information and advice on a planned parasite control program, consult your veterinarian.

Environmental Safety
Studies indicate that when eprinomectin comes in contact with the soil it readily and tightly binds to the soil and becomes inactive over time.  Free ivermectin/eprinomectin may adversely affect fish and certain aquatic organisms.  Do not contaminate water by direct application or by the improper disposal of drug containers.  Dispose of containers in an approved landfill or by incineration.

As with other avermectins, eprinomectin is excreted in the drug of treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction.  The magnitude and duration of such effects are species and life-cycle specific.  When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependent insects.

ADVERSE REACTIONS
No adverse reactions were observed during clinical trials.

STORAGE CONDITIONS
Store bottle or pack in the carton to protect from light and at temperatures up to 86°F/30°C.  Storage at temperatures up to 104°F/40°C is permitted for a short period of time, however, such exposure should be minimized.

HOW SUPPLIED
iVOMEC EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle is available in a 250 mL/8.5  fl oz (302501) or 1 L/33.8 fl oz (302511) bottle with a squeeze-measure-pour system, or ina 2.5 L/84.5 fl oz (302521) or 5 L/169 fl oz (302531 collapsible pack or 20 L/676 fl oz (194991) container intended for use with appropriate automatic dosing equipment.

IVOMEC, EPRINEX, and Cattle Head Logo are registered trademarks of Merial.

MERIAL LTD.
3239 SATELLITE BLVD.
DULUTH, GA 30096
1-888-637-4251

www.merial.com
 

 
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